This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for WDR45. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR45 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR45, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:48,801,126–48,802,845 | 299.3 kb | Distal (>10kb) Multiome | 734 | |
| chrX:48,891,080–48,891,988 | 209.4 kb | Distal (>10kb) Multiome | 525 | |
| chrX:48,897,163–48,898,345 | 203.2 kb | Distal (>10kb) Multiome | 672 | |
| chrX:48,911,574–48,912,414 | 189.2 kb | Distal (>10kb) Multiome | 671 | |
| chrX:48,917,179–48,917,999 | 183.7 kb | Distal (>10kb) Multiome | 468 | |
| chrX:48,918,412–48,919,792 | 182.0 kb | Distal (>10kb) Multiome | 693 | |
| chrX:48,957,469–48,959,105 | 142.8 kb | Distal (>10kb) Multiome | 722 | |
| chrX:49,001,538–49,002,676 | 98.8 kb | Distal (>10kb) Multiome | 540 | |
| chrX:49,039,840–49,040,493 | 61.1 kb | Distal (>10kb) Multiome | 436 | |
| chrX:49,042,954–49,044,182 | 57.5 kb | Distal (>10kb) Multiome | 664 | |
| chrX:49,053,328–49,054,050 | 47.5 kb | Distal (>10kb) Multiome | 403 | |
| chrX:49,071,863–49,072,612 | 29.0 kb | Distal (>10kb) Multiome | 107 | |
| chrX:49,073,903–49,074,451 | 27.1 kb | Distal (>10kb) Multiome | 464 | |
| chrX:49,079,837–49,080,275 | at TSS | At TSS | 649 | |
| chrX:49,100,885–49,101,855 | 121 bp | At TSS Multiome | 562 | |
| chrX:49,155,633–49,156,658 | 55.0 kb | Distal (>10kb) Multiome | 524 | |
| chrX:49,163,555–49,164,377 | 62.9 kb | Distal (>10kb) Multiome | 485 | |
| chrX:49,166,140–49,166,713 | 65.3 kb | Distal (>10kb) Multiome | 416 | |
| chrX:49,184,219–49,185,254 | 83.4 kb | Distal (>10kb) Multiome | 389 | |
| chrX:49,186,113–49,186,660 | 85.3 kb | Distal (>10kb) Multiome | 589 | |
| chrX:49,190,730–49,191,899 | 90.0 kb | Distal (>10kb) Multiome | 636 | |
| chrX:49,199,793–49,200,448 | 99.0 kb | Distal (>10kb) Multiome | 806 | |
| chrX:49,230,792–49,231,268 | 129.9 kb | Distal (>10kb) Multiome | 221 | |
| chrX:49,268,786–49,270,236 | 168.2 kb | Distal (>10kb) Multiome | 603 |
Genomic view of the WDR45 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.