This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. A similar protein in mouse is thought to be a negative regulator of the pancreatic beta cell proliferation. Mice lacking this gene exhibit increased pancreatic islet mass and higher serum insulin levels, and are mildly obese. [provided by RefSeq, Nov 2016]
Transcription factors with Perturb-seq knockdown data for WDR13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:48,475,845–48,476,469 | 121.4 kb | Distal (>10kb) Multiome | 613 | |
| chrX:48,508,766–48,509,247 | 88.6 kb | Distal (>10kb) Multiome | 400 | |
| chrX:48,521,369–48,522,158 | 75.8 kb | Distal (>10kb) Multiome | 519 | |
| chrX:48,539,185–48,540,294 | 57.9 kb | Distal (>10kb) Multiome | 658 | |
| chrX:48,574,090–48,575,023 | 22.9 kb | Distal (>10kb) Multiome | 779 | |
| chrX:48,597,350–48,598,476 | 371 bp | At TSS Multiome | 660 | |
| chrX:48,676,132–48,677,132 | 79.0 kb | Distal (>10kb) Multiome | 642 | |
| chrX:48,695,862–48,697,105 | 99.1 kb | Distal (>10kb) Multiome | 600 | |
| chrX:48,737,116–48,737,756 | 139.9 kb | Distal (>10kb) Multiome | 580 | |
| chrX:48,801,126–48,802,845 | 204.4 kb | Distal (>10kb) Multiome | 734 | |
| chrX:48,891,080–48,891,988 | 294.2 kb | Distal (>10kb) Multiome | 525 | |
| chrX:48,897,163–48,898,345 | 300.4 kb | Distal (>10kb) Multiome | 672 |
Genomic view of the WDR13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.