Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for VWA5B1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VWA5B1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VWA5B1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:20,152,028–20,152,628 | 138.4 kb | Distal (>10kb) Multiome | 449 | |
| chr1:20,185,802–20,186,675 | 104.8 kb | Distal (>10kb) Multiome | 444 | |
| chr1:20,213,009–20,213,518 | 77.7 kb | Distal (>10kb) Multiome | 361 | |
| chr1:20,290,425–20,291,141 | 89 bp | At TSS Multiome | 203 | |
| chr1:20,342,875–20,344,326 | 52.8 kb | Distal (>10kb) Multiome | 261 | |
| chr1:20,366,975–20,367,437 | 76.4 kb | Distal (>10kb) Multiome | 164 | |
| chr1:20,485,233–20,485,959 | 195.0 kb | Distal (>10kb) Multiome | 348 | |
| chr1:20,486,131–20,487,438 | 196.1 kb | Distal (>10kb) Multiome | 760 | |
| chr1:20,493,822–20,494,241 | 203.2 kb | Distal (>10kb) Multiome | 430 | |
| chr1:20,507,717–20,508,432 | 217.2 kb | Distal (>10kb) Multiome | 811 | |
| chr1:20,552,019–20,553,890 | 262.8 kb | Distal (>10kb) Multiome | 518 |
Genomic view of the VWA5B1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.