Enables SNARE binding activity and chloride channel inhibitor activity. Involved in regulation of protein localization to plasma membrane. Located in several cellular components, including endosome membrane; lysosomal membrane; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for VTI1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VTI1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VTI1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:67,427,006–67,427,629 | 247.3 kb | Distal (>10kb) Multiome | 288 | |
| chr14:67,514,900–67,515,814 | 159.3 kb | Distal (>10kb) Multiome | 411 | |
| chr14:67,532,784–67,533,987 | 141.3 kb | Distal (>10kb) Multiome | 684 | |
| chr14:67,541,829–67,542,290 | 132.6 kb | Distal (>10kb) Multiome | 187 | |
| chr14:67,599,595–67,600,617 | 74.4 kb | Distal (>10kb) Multiome HiCAR | 746 | |
| chr14:67,619,336–67,620,756 | 54.8 kb | Distal (>10kb) Multiome | 794 | |
| chr14:67,674,148–67,675,415 | 158 bp | At TSS Multiome | 840 | |
| chr14:67,694,763–67,695,985 | 20.2 kb | Distal (>10kb) Multiome | 742 | |
| chr14:67,729,052–67,729,527 | 54.7 kb | Distal (>10kb) Multiome | 407 | |
| chr14:67,816,043–67,817,024 | 142.0 kb | Distal (>10kb) Multiome | 712 | |
| chr14:67,819,625–67,820,281 | 145.2 kb | Distal (>10kb) Multiome | 482 | |
| chr14:67,934,038–67,934,596 | 259.7 kb | Distal (>10kb) Multiome | 380 |
Genomic view of the VTI1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.