The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for VPS72. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VPS72 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VPS72, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:150,925,543–150,926,754 | 263.8 kb | Distal (>10kb) Multiome | 813 | |
| chr1:150,973,876–150,975,458 | 215.3 kb | Distal (>10kb) Multiome | 590 | |
| chr1:150,979,331–150,979,990 | 210.6 kb | Distal (>10kb) Multiome | 562 | |
| chr1:150,981,212–150,981,672 | 208.8 kb | Distal (>10kb) Multiome | 379 | |
| chr1:151,006,389–151,007,024 | 183.4 kb | Distal (>10kb) Multiome | 496 | |
| chr1:151,008,116–151,008,852 | 181.7 kb | Distal (>10kb) Multiome | 763 | |
| chr1:151,047,405–151,048,764 | 141.6 kb | Distal (>10kb) Multiome | 714 | |
| chr1:151,059,187–151,059,842 | 130.5 kb | Distal (>10kb) Multiome | 821 | |
| chr1:151,060,204–151,060,723 | 129.6 kb | Distal (>10kb) Multiome | 346 | |
| chr1:151,070,369–151,071,463 | 119.0 kb | Distal (>10kb) Multiome | 835 | |
| chr1:151,131,105–151,132,256 | 58.7 kb | Distal (>10kb) Multiome | 247 | |
| chr1:151,145,115–151,147,333 | 43.4 kb | Distal (>10kb) Multiome | 709 | |
| chr1:151,165,133–151,166,350 | 24.3 kb | Distal (>10kb) Multiome | 940 | |
| chr1:151,189,687–151,190,378 | 1 bp | At TSS Multiome | 875 | |
| chr1:151,198,185–151,199,073 | 8.4 kb | Proximal (<10kb) Multiome | 721 | |
| chr1:151,254,421–151,255,083 | 64.6 kb | Distal (>10kb) Multiome | 770 | |
| chr1:151,281,008–151,283,557 | 91.2 kb | Distal (>10kb) Multiome | 1121 | |
| chr1:151,327,019–151,328,343 | 137.5 kb | Distal (>10kb) Multiome | 719 | |
| chr1:151,346,796–151,347,793 | 157.1 kb | Distal (>10kb) Multiome | 711 | |
| chr1:151,399,359–151,400,043 | 209.4 kb | Distal (>10kb) Multiome | 776 | |
| chr1:151,458,247–151,459,879 | 269.3 kb | Distal (>10kb) Multiome | 796 |
Genomic view of the VPS72 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.