This gene encodes a chaperone for assembly of lysosomal vacuolar ATPase.[provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for VMA21. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VMA21 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VMA21, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:151,175,898–151,178,232 | 220.7 kb | Distal (>10kb) Multiome | 212 | |
| chrX:151,393,625–151,393,818 | 3.4 kb | Proximal (<10kb) | 38 | |
| chrX:151,396,617–151,397,655 | 52 bp | At TSS Multiome | 672 | |
| chrX:151,694,535–151,695,747 | 297.9 kb | Distal (>10kb) Multiome | 156 |
Genomic view of the VMA21 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.