This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for VIPR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VIPR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VIPR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:42,264,672–42,265,502 | 237.6 kb | Distal (>10kb) Multiome HiCAR | 182 | |
| chr3:42,270,524–42,271,571 | 231.7 kb | Distal (>10kb) Multiome | 132 | |
| chr3:42,349,668–42,350,325 | 152.7 kb | Distal (>10kb) Multiome | 246 | |
| chr3:42,446,025–42,446,484 | 56.3 kb | Distal (>10kb) Multiome | 27 | |
| chr3:42,501,285–42,503,228 | 59 bp | At TSS Multiome | 508 | |
| chr3:42,507,296–42,507,651 | 4.7 kb | Proximal (<10kb) | 127 | |
| chr3:42,581,475–42,582,842 | 79.5 kb | Distal (>10kb) Multiome | 889 | |
| chr3:42,590,205–42,591,365 | 88.1 kb | Distal (>10kb) Multiome | 646 | |
| chr3:42,600,083–42,601,438 | 98.0 kb | Distal (>10kb) Multiome | 914 | |
| chr3:42,653,440–42,655,446 | 152.0 kb | Distal (>10kb) Multiome | 631 | |
| chr3:42,772,623–42,773,428 | 270.6 kb | Distal (>10kb) Multiome | 446 |
Genomic view of the VIPR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.