The protein encoded by this gene belongs to the villin/gelsolin family. It contains 6 gelsolin-like repeats and a headpiece domain. It may play a role in actin-bundling. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for VILL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VILL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VILL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:37,986,618–37,987,603 | 3.2 kb | Proximal (<10kb) | 525 | |
| chr3:37,992,479–37,993,259 | 1.7 kb | Proximal (<10kb) | 141 | |
| chr3:37,993,686–37,994,594 | 2.9 kb | Proximal (<10kb) | 519 | |
| chr3:37,996,811–37,997,297 | 6.0 kb | Proximal (<10kb) | 370 | |
| chr3:37,998,336–37,999,630 | 7.6 kb | Proximal (<10kb) | 510 |
Genomic view of the VILL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.