Enables ATPase binding activity and protein-lysine N-methyltransferase activity. Involved in negative regulation of ATP-dependent activity and peptidyl-lysine trimethylation. Located in cytosol. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for VCPKMT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VCPKMT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VCPKMT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:49,852,270–49,853,410 | 263.8 kb | Distal (>10kb) Multiome | 813 | |
| chr14:49,853,662–49,854,089 | 262.6 kb | Distal (>10kb) Multiome | 439 | |
| chr14:49,861,592–49,863,464 | 253.7 kb | Distal (>10kb) Multiome HiCAR | 1038 | |
| chr14:49,867,745–49,868,682 | 248.3 kb | Distal (>10kb) Multiome HiCAR | 699 | |
| chr14:49,892,363–49,894,019 | 223.6 kb | Distal (>10kb) Multiome HiCAR | 981 | |
| chr14:50,000,183–50,001,939 | 115.2 kb | Distal (>10kb) Multiome | 669 | |
| chr14:50,116,214–50,116,984 | 34 bp | At TSS Multiome | 818 | |
| chr14:50,231,069–50,232,486 | 115.2 kb | Distal (>10kb) Multiome | 823 | |
| chr14:50,311,389–50,313,095 | 195.7 kb | Distal (>10kb) Multiome | 986 | |
| chr14:50,396,285–50,397,366 | 280.3 kb | Distal (>10kb) Multiome | 782 |
Genomic view of the VCPKMT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.