Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of vesicles and cell membranes. The VAMP5 gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and the SNARE superfamily. This VAMP family member may participate in vesicle trafficking events that are associated with myogenesis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for VAMP5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VAMP5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VAMP5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:85,327,503–85,328,538 | 256.4 kb | Distal (>10kb) Multiome | 1009 | |
| chr2:85,354,014–85,355,224 | 229.8 kb | Distal (>10kb) Multiome | 962 | |
| chr2:85,418,133–85,419,210 | 165.8 kb | Distal (>10kb) Multiome | 885 | |
| chr2:85,420,473–85,421,406 | 163.6 kb | Distal (>10kb) Multiome | 853 | |
| chr2:85,437,445–85,438,463 | 146.6 kb | Distal (>10kb) Multiome | 501 | |
| chr2:85,455,501–85,456,436 | 128.5 kb | Distal (>10kb) Multiome | 268 | |
| chr2:85,468,626–85,469,195 | 115.6 kb | Distal (>10kb) Multiome | 496 | |
| chr2:85,537,623–85,540,152 | 46.7 kb | Distal (>10kb) Multiome | 1210 | |
| chr2:85,561,042–85,561,982 | 22.9 kb | Distal (>10kb) Multiome | 903 | |
| chr2:85,577,411–85,578,045 | 6.9 kb | Proximal (<10kb) Multiome | 505 | |
| chr2:85,578,935–85,580,041 | 4.8 kb | Proximal (<10kb) Multiome | 275 | |
| chr2:85,584,249–85,584,853 | at TSS | At TSS | 633 | |
| chr2:85,595,068–85,596,226 | 11.2 kb | Distal (>10kb) Multiome | 804 | |
| chr2:85,601,954–85,603,493 | 18.3 kb | Distal (>10kb) Multiome | 852 | |
| chr2:85,611,558–85,612,589 | 27.6 kb | Distal (>10kb) Multiome | 875 | |
| chr2:85,615,831–85,616,609 | 31.7 kb | Distal (>10kb) Multiome | 898 | |
| chr2:85,678,904–85,679,599 | 94.9 kb | Distal (>10kb) Multiome | 445 | |
| chr2:85,753,145–85,755,032 | 169.4 kb | Distal (>10kb) Multiome | 527 | |
| chr2:85,827,451–85,827,914 | 243.2 kb | Distal (>10kb) Multiome | 364 |
Genomic view of the VAMP5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.