Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for VAMP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VAMP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VAMP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:171,484,908–171,486,487 | 256.6 kb | Distal (>10kb) Multiome | 978 | |
| chr1:171,508,885–171,509,949 | 232.7 kb | Distal (>10kb) Multiome | 157 | |
| chr1:171,641,225–171,641,935 | 100.5 kb | Distal (>10kb) Multiome | 208 | |
| chr1:171,644,792–171,645,779 | 96.9 kb | Distal (>10kb) Multiome | 424 | |
| chr1:171,664,751–171,665,757 | 76.8 kb | Distal (>10kb) Multiome | 206 | |
| chr1:171,741,356–171,742,843 | 58 bp | At TSS Multiome | 906 | |
| chr1:171,780,733–171,782,347 | 39.4 kb | Distal (>10kb) Multiome | 902 | |
| chr1:171,840,670–171,842,693 | 99.3 kb | Distal (>10kb) Multiome | 572 |
Genomic view of the VAMP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.