This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for UTRN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UTRN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UTRN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:144,007,743–144,008,869 | 277.0 kb | Distal (>10kb) Multiome | 500 | |
| chr6:144,063,633–144,064,850 | 221.2 kb | Distal (>10kb) Multiome | 823 | |
| chr6:144,094,958–144,096,613 | 189.6 kb | Distal (>10kb) Multiome | 1009 | |
| chr6:144,149,717–144,151,586 | 134.8 kb | Distal (>10kb) Multiome | 708 | |
| chr6:144,215,237–144,217,057 | 68.9 kb | Distal (>10kb) Multiome | 1073 | |
| chr6:144,278,760–144,279,218 | 6.1 kb | Proximal (<10kb) | 119 | |
| chr6:144,284,589–144,287,497 | 221 bp | At TSS Multiome | 1050 | |
| chr6:144,322,249–144,322,626 | 8.2 kb | Proximal (<10kb) | 157 | |
| chr6:144,326,997–144,327,723 | 3.1 kb | Proximal (<10kb) | 85 | |
| chr6:144,330,551–144,331,098 | 45.4 kb | Distal (>10kb) Multiome | 251 |
Genomic view of the UTRN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.