This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for USP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = USP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of USP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:119,067,446–119,068,100 | 296.5 kb | Distal (>10kb) Multiome | 762 | |
| chr11:119,084,563–119,085,756 | 279.2 kb | Distal (>10kb) Multiome | 846 | |
| chr11:119,093,969–119,096,070 | 268.6 kb | Distal (>10kb) Multiome | 1046 | |
| chr11:119,101,351–119,102,791 | 262.1 kb | Distal (>10kb) Multiome | 871 | |
| chr11:119,106,906–119,107,993 | 256.9 kb | Distal (>10kb) Multiome | 650 | |
| chr11:119,120,857–119,122,037 | 242.7 kb | Distal (>10kb) Multiome | 787 | |
| chr11:119,144,795–119,145,355 | 219.1 kb | Distal (>10kb) Multiome | 230 | |
| chr11:119,148,816–119,149,933 | 214.6 kb | Distal (>10kb) Multiome | 262 | |
| chr11:119,168,601–119,169,645 | 195.3 kb | Distal (>10kb) Multiome | 794 | |
| chr11:119,205,241–119,207,150 | 158.1 kb | Distal (>10kb) Multiome | 695 | |
| chr11:119,315,017–119,315,819 | 48.9 kb | Distal (>10kb) Multiome | 270 | |
| chr11:119,316,693–119,317,760 | 47.0 kb | Distal (>10kb) Multiome | 463 | |
| chr11:119,320,617–119,321,906 | 42.4 kb | Distal (>10kb) Multiome | 516 | |
| chr11:119,334,140–119,334,815 | 29.8 kb | Distal (>10kb) Multiome | 577 | |
| chr11:119,337,716–119,338,797 | 25.9 kb | Distal (>10kb) Multiome | 412 | |
| chr11:119,339,587–119,340,902 | 24.1 kb | Distal (>10kb) Multiome | 477 | |
| chr11:119,356,332–119,357,013 | 7.5 kb | Proximal (<10kb) Multiome | 366 | |
| chr11:119,361,041–119,361,699 | 2.9 kb | Proximal (<10kb) Multiome | 431 | |
| chr11:119,363,939–119,364,561 | 17 bp | At TSS Multiome | 255 | |
| chr11:119,374,233–119,374,466 | 4.6 kb | Proximal (<10kb) | 267 | |
| chr11:119,374,950–119,375,101 | 4.0 kb | Proximal (<10kb) | 142 | |
| chr11:119,377,954–119,379,307 | 14.3 kb | Distal (>10kb) Multiome | 307 | |
| chr11:119,380,894–119,382,060 | 17.5 kb | Distal (>10kb) Multiome | 800 | |
| chr11:119,389,976–119,390,165 | 8.3 kb | Proximal (<10kb) | 53 | |
| chr11:119,422,349–119,423,771 | 59.0 kb | Distal (>10kb) Multiome | 235 | |
| chr11:119,481,243–119,481,846 | 117.4 kb | Distal (>10kb) Multiome | 592 | |
| chr11:119,584,125–119,585,601 | 220.2 kb | Distal (>10kb) Multiome | 491 | |
| chr11:119,616,862–119,617,652 | 252.9 kb | Distal (>10kb) Multiome | 70 |
Genomic view of the USP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.