Enables sulfur carrier activity. Involved in tRNA thio-modification and tRNA wobble uridine modification. Predicted to be located in cytosol. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for URM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = URM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of URM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:128,097,872–128,098,910 | 273.0 kb | Distal (>10kb) Multiome | 712 | |
| chr9:128,117,658–128,118,328 | 253.5 kb | Distal (>10kb) Multiome | 640 | |
| chr9:128,127,314–128,128,793 | 243.1 kb | Distal (>10kb) Multiome | 899 | |
| chr9:128,159,371–128,160,928 | 211.2 kb | Distal (>10kb) Multiome | 824 | |
| chr9:128,191,300–128,192,050 | 179.7 kb | Distal (>10kb) Multiome | 865 | |
| chr9:128,203,004–128,204,704 | 167.0 kb | Distal (>10kb) Multiome | 690 | |
| chr9:128,218,656–128,219,107 | 152.5 kb | Distal (>10kb) Multiome | 410 | |
| chr9:128,250,012–128,251,099 | 120.8 kb | Distal (>10kb) Multiome | 353 | |
| chr9:128,275,636–128,276,535 | 95.3 kb | Distal (>10kb) Multiome | 728 | |
| chr9:128,322,183–128,322,933 | 48.8 kb | Distal (>10kb) Multiome | 962 | |
| chr9:128,340,070–128,341,161 | 30.9 kb | Distal (>10kb) Multiome | 803 | |
| chr9:128,362,219–128,362,416 | 9.0 kb | Proximal (<10kb) | 451 | |
| chr9:128,364,858–128,365,437 | 6.3 kb | Proximal (<10kb) Multiome | 442 | |
| chr9:128,371,148–128,371,453 | at TSS | At TSS | 611 | |
| chr9:128,420,259–128,421,260 | 49.4 kb | Distal (>10kb) Multiome | 701 | |
| chr9:128,455,721–128,456,522 | 84.7 kb | Distal (>10kb) Multiome | 684 | |
| chr9:128,504,482–128,505,188 | 133.3 kb | Distal (>10kb) Multiome | 766 | |
| chr9:128,552,006–128,553,125 | 181.1 kb | Distal (>10kb) Multiome | 839 | |
| chr9:128,656,436–128,657,126 | 285.5 kb | Distal (>10kb) Multiome | 1009 |
Genomic view of the URM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.