UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]
Transcription factors with Perturb-seq knockdown data for UNC5A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UNC5A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UNC5A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:176,536,385–176,538,671 | 273.1 kb | Distal (>10kb) Multiome | 1006 | |
| chr5:176,541,333–176,544,229 | 267.0 kb | Distal (>10kb) Multiome | 733 | |
| chr5:176,596,638–176,597,570 | 213.5 kb | Distal (>10kb) Multiome | 234 | |
| chr5:176,609,466–176,610,727 | 200.5 kb | Distal (>10kb) Multiome | 544 | |
| chr5:176,618,956–176,619,934 | 191.2 kb | Distal (>10kb) Multiome | 328 | |
| chr5:176,630,050–176,630,816 | 180.1 kb | Distal (>10kb) Multiome | 352 | |
| chr5:176,646,726–176,648,437 | 163.2 kb | Distal (>10kb) Multiome | 701 | |
| chr5:176,660,849–176,661,318 | 149.5 kb | Distal (>10kb) Multiome HiCAR | 382 | |
| chr5:176,809,543–176,810,815 | 182 bp | At TSS Multiome | 404 | |
| chr5:176,812,893–176,813,091 | 2.4 kb | Proximal (<10kb) | 252 | |
| chr5:176,817,316–176,818,386 | 7.4 kb | Proximal (<10kb) Multiome | 358 | |
| chr5:177,005,819–177,007,175 | 196.1 kb | Distal (>10kb) Multiome | 972 | |
| chr5:177,022,405–177,023,229 | 212.2 kb | Distal (>10kb) Multiome | 767 | |
| chr5:177,086,049–177,087,797 | 276.3 kb | Distal (>10kb) Multiome | 867 |
Genomic view of the UNC5A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.