Transcription factors with Perturb-seq knockdown data for UMAD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UMAD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UMAD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:7,352,864–7,353,400 | 287.7 kb | Distal (>10kb) Multiome | 139 | |
| chr7:7,415,971–7,416,912 | 224.5 kb | Distal (>10kb) Multiome | 282 | |
| chr7:7,566,155–7,567,492 | 73.8 kb | Distal (>10kb) Multiome | 741 | |
| chr7:7,581,435–7,582,116 | 58.9 kb | Distal (>10kb) Multiome | 224 | |
| chr7:7,640,013–7,641,632 | 111 bp | At TSS Multiome | 966 | |
| chr7:7,834,519–7,835,290 | 194.2 kb | Distal (>10kb) Multiome | 123 | |
| chr7:7,921,959–7,922,972 | 281.8 kb | Distal (>10kb) Multiome | 215 |
Genomic view of the UMAD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.