This gene encodes a member of the unc-51-like serine/threonine kinase (STK) family. Members of this protein family play a role in neuronal growth and endocytosis. The encoded protein is likely involved in neurite branching, neurite elongation and neuronal migration. Genome-wide association studies (GWAS) indicate an association of variations in this gene with blood pressure and hypertension. Sequence variations in this gene may also be be associated with psychiatric disorders, including schizophrenia and bipolar disorder. Pseudogenes associated with this gene have been identified and are located on chromosome 15. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for ULK4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ULK4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ULK4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:40,308,903–40,310,435 | 1652.4 kb | Distal (>10kb) Multiome HiCAR | 940 | |
| chr3:40,452,726–40,453,738 | 1508.8 kb | Distal (>10kb) Multiome HiCAR | 787 | |
| chr3:40,456,939–40,457,754 | 1504.7 kb | Distal (>10kb) Multiome HiCAR | 794 | |
| chr3:41,961,164–41,962,778 | 180 bp | At TSS Multiome | 829 | |
| chr3:42,012,939–42,014,361 | 51.5 kb | Distal (>10kb) Multiome | 723 | |
| chr3:42,023,321–42,024,092 | 61.5 kb | Distal (>10kb) Multiome | 142 | |
| chr3:42,025,591–42,026,077 | 63.7 kb | Distal (>10kb) Multiome | 400 | |
| chr3:42,042,809–42,043,844 | 81.3 kb | Distal (>10kb) Multiome | 435 | |
| chr3:42,159,717–42,160,505 | 198.0 kb | Distal (>10kb) Multiome | 491 |
Genomic view of the ULK4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.