Enables cysteine-type deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Involved in several processes, including positive regulation of smoothened signaling pathway; protein deubiquitination; and regulation of primary metabolic process. Located in cytosol and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UCHL5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UCHL5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UCHL5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:192,808,061–192,809,823 | 250.5 kb | Distal (>10kb) Multiome | 926 | |
| chr1:193,058,504–193,060,296 | 145 bp | At TSS Multiome | 1176 | |
| chr1:193,062,157–193,062,293 | 2.8 kb | Proximal (<10kb) | 20 | |
| chr1:193,068,555–193,068,701 | 9.2 kb | Proximal (<10kb) | 49 | |
| chr1:193,104,306–193,105,941 | 46.1 kb | Distal (>10kb) Multiome | 926 | |
| chr1:193,113,187–193,113,979 | 54.1 kb | Distal (>10kb) Multiome | 295 | |
| chr1:193,121,459–193,122,720 | 62.6 kb | Distal (>10kb) Multiome | 1102 |
Genomic view of the UCHL5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.