Transcription factors with Perturb-seq knockdown data for UBR5-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBR5-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBR5-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:102,123,582–102,124,596 | 115.3 kb | Distal (>10kb) Multiome | 301 | |
| chr8:102,238,283–102,240,136 | 170 bp | At TSS Multiome | 1019 | |
| chr8:102,411,265–102,413,321 | 173.5 kb | Distal (>10kb) Multiome | 983 | |
| chr8:102,528,491–102,529,202 | 289.5 kb | Distal (>10kb) Multiome | 532 | |
| chr8:102,535,757–102,536,632 | 296.7 kb | Distal (>10kb) Multiome | 367 |
Genomic view of the UBR5-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.