Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including sensory perception of smell; suckling behavior; and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Predicted to act upstream of or within in utero embryonic development and olfactory behavior. Predicted to be located in membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UBR3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBR3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBR3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:169,573,179–169,574,073 | 253.6 kb | Distal (>10kb) Multiome | 834 | |
| chr2:169,584,221–169,584,891 | 243.0 kb | Distal (>10kb) Multiome | 994 | |
| chr2:169,694,097–169,694,854 | 133.0 kb | Distal (>10kb) Multiome | 898 | |
| chr2:169,733,252–169,734,532 | 93.5 kb | Distal (>10kb) Multiome | 735 | |
| chr2:169,789,706–169,790,238 | 37.5 kb | Distal (>10kb) Multiome | 539 | |
| chr2:169,798,658–169,799,453 | 28.5 kb | Distal (>10kb) Multiome | 794 | |
| chr2:169,824,413–169,825,252 | 2.5 kb | Proximal (<10kb) Multiome | 946 | |
| chr2:169,827,076–169,828,199 | 13 bp | At TSS Multiome | 760 | |
| chr2:169,828,363–169,828,704 | 910 bp | At TSS | 262 |
Genomic view of the UBR3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.