UBL4A
ubiquitin like 4A | DXS254E, GDX, GET5, MDY2, TMA24, UBL4

Enables protein-folding chaperone binding activity. Involved in establishment of protein localization to membrane; regulation of protein stability; and ubiquitin-dependent protein catabolic process. Located in cytosol; membrane; and nucleoplasm. Part of BAT3 complex. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 23 terms
BAT3 complex (GO:0071818)BAT3 complex (GO:0071818)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)membrane (GO:0016020)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)post-translational protein targeting to endoplasmic reticulum membrane (GO:0006620)post-translational protein targeting to endoplasmic reticulum membrane (GO:0006620)post-translational protein targeting to endoplasmic reticulum membrane (GO:0006620)protein binding (GO:0005515)protein modification process (GO:0036211)protein-folding chaperone binding (GO:0051087)protein-folding chaperone binding (GO:0051087)regulation of protein stability (GO:0031647)tail-anchored membrane protein insertion into ER membrane (GO:0071816)tail-anchored membrane protein insertion into ER membrane (GO:0071816)tail-anchored membrane protein insertion into ER membrane (GO:0071816)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-like protein transferase activity (GO:0019787)
Expression (TPM)
UBL4A — as a Regulated Gene

TFs regulating UBL4A 0 TFs

Transcription factors with Perturb-seq knockdown data for UBL4A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBL4A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to UBL4A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBL4A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chrX:154,368,993–154,370,053 117.0 kb Distal (>10kb) Multiome 546
chrX:154,370,757–154,372,188 115.2 kb Distal (>10kb) Multiome 764
chrX:154,378,063–154,379,701 107.6 kb Distal (>10kb) Multiome 687
chrX:154,397,430–154,398,941 88.4 kb Distal (>10kb) Multiome 871
chrX:154,409,052–154,409,671 77.3 kb Distal (>10kb) Multiome 396
chrX:154,428,419–154,428,969 58.0 kb Distal (>10kb) Multiome 601
chrX:154,436,501–154,437,435 49.7 kb Distal (>10kb) Multiome 448
chrX:154,443,986–154,444,454 42.5 kb Distal (>10kb) Multiome 329
chrX:154,457,605–154,458,763 28.5 kb Distal (>10kb) Multiome 467
chrX:154,478,385–154,479,590 7.5 kb Proximal (<10kb) Multiome 707
chrX:154,486,385–154,487,035 157 bp At TSS Multiome 437
chrX:154,490,259–154,491,245 4.2 kb Proximal (<10kb) Multiome 567
chrX:154,515,811–154,517,059 29.8 kb Distal (>10kb) Multiome 590
chrX:154,546,514–154,547,906 60.6 kb Distal (>10kb) Multiome 691
chrX:154,762,385–154,763,339 276.2 kb Distal (>10kb) Multiome 675

Genome Browser

Genomic view of the UBL4A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chrX:154,358,993 – 154,773,339
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact