This gene encodes a protein thought to be involved in cholesterol and phospholipid metabolism. Mutations in this gene are associated with Schnyder crystalline corneal dystrophy. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for UBIAD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBIAD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBIAD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:11,011,823–11,013,364 | 260.7 kb | Distal (>10kb) Multiome | 974 | |
| chr1:11,052,805–11,053,698 | 219.9 kb | Distal (>10kb) Multiome | 314 | |
| chr1:11,059,469–11,060,508 | 213.1 kb | Distal (>10kb) Multiome | 659 | |
| chr1:11,099,300–11,100,191 | 173.4 kb | Distal (>10kb) Multiome | 798 | |
| chr1:11,262,158–11,262,957 | 10.5 kb | Distal (>10kb) Multiome | 805 | |
| chr1:11,272,615–11,274,143 | 65 bp | At TSS Multiome | 912 | |
| chr1:11,311,832–11,312,672 | 39.1 kb | Distal (>10kb) Multiome | 49 | |
| chr1:11,478,503–11,480,383 | 205.8 kb | Distal (>10kb) Multiome | 732 | |
| chr1:11,563,348–11,564,005 | 290.5 kb | Distal (>10kb) Multiome | 272 |
Genomic view of the UBIAD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.