Enables cyclin binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein conjugating enzyme binding activity. Involved in protein autoubiquitination; protein monoubiquitination; and protein polyubiquitination. Part of ubiquitin ligase complex. Is active in cytosol. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for UBE3D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBE3D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBE3D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:82,246,942–82,248,798 | 818.1 kb | Distal (>10kb) Multiome HiCAR | 957 | |
| chr6:82,256,786–82,258,089 | 808.5 kb | Distal (>10kb) Multiome HiCAR | 171 | |
| chr6:82,363,222–82,366,030 | 702.0 kb | Distal (>10kb) Multiome HiCAR | 857 | |
| chr6:83,057,819–83,057,995 | 7.8 kb | Proximal (<10kb) | 85 | |
| chr6:83,065,409–83,066,246 | 2 bp | At TSS Multiome | 863 | |
| chr6:83,067,273–83,069,447 | 2.1 kb | Proximal (<10kb) Multiome | 1006 | |
| chr6:83,192,782–83,194,476 | 127.5 kb | Distal (>10kb) Multiome | 948 | |
| chr6:83,511,480–83,513,126 | 446.5 kb | Distal (>10kb) Multiome HiCAR | 450 |
Genomic view of the UBE3D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.