Transcription factors with Perturb-seq knockdown data for UBALD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBALD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBALD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:4,315,041–4,316,747 | 299.2 kb | Distal (>10kb) Multiome | 520 | |
| chr16:4,327,446–4,328,634 | 286.7 kb | Distal (>10kb) Multiome | 495 | |
| chr16:4,350,579–4,351,773 | 263.7 kb | Distal (>10kb) Multiome | 674 | |
| chr16:4,371,473–4,372,791 | 243.2 kb | Distal (>10kb) Multiome | 617 | |
| chr16:4,402,485–4,403,104 | 212.3 kb | Distal (>10kb) Multiome | 450 | |
| chr16:4,415,818–4,417,201 | 198.3 kb | Distal (>10kb) Multiome | 681 | |
| chr16:4,425,392–4,426,322 | 189.3 kb | Distal (>10kb) Multiome | 881 | |
| chr16:4,474,111–4,474,929 | 140.4 kb | Distal (>10kb) Multiome | 626 | |
| chr16:4,476,027–4,477,237 | 138.6 kb | Distal (>10kb) Multiome | 841 | |
| chr16:4,537,639–4,538,998 | 76.4 kb | Distal (>10kb) Multiome HiCAR | 1087 | |
| chr16:4,585,331–4,585,992 | 29.4 kb | Distal (>10kb) Multiome | 223 | |
| chr16:4,613,912–4,617,164 | 120 bp | At TSS Multiome | 1079 | |
| chr16:4,624,301–4,625,703 | 9.7 kb | Proximal (<10kb) Multiome | 866 | |
| chr16:4,693,016–4,694,663 | 78.6 kb | Distal (>10kb) Multiome | 730 | |
| chr16:4,733,836–4,735,221 | 119.4 kb | Distal (>10kb) Multiome | 858 | |
| chr16:4,766,728–4,767,628 | 152.2 kb | Distal (>10kb) Multiome | 795 | |
| chr16:4,768,438–4,769,162 | 153.8 kb | Distal (>10kb) Multiome | 677 | |
| chr16:4,801,836–4,803,175 | 187.3 kb | Distal (>10kb) Multiome | 743 | |
| chr16:4,846,559–4,848,209 | 232.4 kb | Distal (>10kb) Multiome | 803 |
Genomic view of the UBALD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.