Enables polyubiquitin modification-dependent protein binding activity and proteasome binding activity. Involved in protein maturation and protein ubiquitination. Located in Golgi apparatus; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UBAC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBAC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBAC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:135,906,558–135,908,509 | 53.6 kb | Distal (>10kb) Multiome | 772 | |
| chr9:135,960,610–135,961,627 | 166 bp | At TSS Multiome | 697 | |
| chr9:135,967,611–135,967,821 | 6.4 kb | Proximal (<10kb) | 518 | |
| chr9:135,992,635–135,993,405 | 31.9 kb | Distal (>10kb) Multiome | 684 | |
| chr9:136,051,068–136,051,829 | 90.3 kb | Distal (>10kb) Multiome | 353 | |
| chr9:136,094,901–136,095,992 | 134.3 kb | Distal (>10kb) Multiome | 445 | |
| chr9:136,109,321–136,110,010 | 148.4 kb | Distal (>10kb) Multiome HiCAR | 643 | |
| chr9:136,117,952–136,119,826 | 157.6 kb | Distal (>10kb) Multiome HiCAR | 931 | |
| chr9:136,132,442–136,133,645 | 172.0 kb | Distal (>10kb) Multiome HiCAR | 343 | |
| chr9:136,245,219–136,246,310 | 284.6 kb | Distal (>10kb) Multiome | 608 |
Genomic view of the UBAC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.