This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for TYSND1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TYSND1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TYSND1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:70,052,471–70,054,619 | 93.8 kb | Distal (>10kb) Multiome | 577 | |
| chr10:70,132,124–70,133,061 | 13.9 kb | Distal (>10kb) Multiome | 729 | |
| chr10:70,142,275–70,142,773 | 3.9 kb | Proximal (<10kb) | 9 | |
| chr10:70,145,328–70,147,235 | 1.0 kb | Proximal (<10kb) Multiome | 1006 | |
| chr10:70,169,902–70,171,034 | 24.0 kb | Distal (>10kb) Multiome | 777 | |
| chr10:70,232,204–70,234,260 | 86.9 kb | Distal (>10kb) Multiome | 949 | |
| chr10:70,381,835–70,383,091 | 236.0 kb | Distal (>10kb) Multiome | 693 | |
| chr10:70,403,687–70,404,709 | 257.4 kb | Distal (>10kb) Multiome | 788 | |
| chr10:70,439,787–70,443,007 | 295.9 kb | Distal (>10kb) Multiome | 501 |
Genomic view of the TYSND1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.