This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35. [provided by RefSeq, Sep 2020]
Transcription factors with Perturb-seq knockdown data for TYK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TYK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TYK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:10,086,000–10,086,942 | 294.2 kb | Distal (>10kb) Multiome | 614 | |
| chr19:10,095,848–10,096,951 | 284.3 kb | Distal (>10kb) Multiome | 572 | |
| chr19:10,106,123–10,106,748 | 274.2 kb | Distal (>10kb) Multiome | 842 | |
| chr19:10,113,011–10,113,478 | 267.3 kb | Distal (>10kb) Multiome | 511 | |
| chr19:10,119,464–10,120,287 | 260.6 kb | Distal (>10kb) Multiome | 818 | |
| chr19:10,194,229–10,195,372 | 185.6 kb | Distal (>10kb) Multiome | 939 | |
| chr19:10,230,671–10,231,665 | 149.1 kb | Distal (>10kb) Multiome | 595 | |
| chr19:10,251,723–10,252,663 | 128.5 kb | Distal (>10kb) Multiome HiCAR | 969 | |
| chr19:10,269,513–10,270,051 | 110.9 kb | Distal (>10kb) Multiome HiCAR | 523 | |
| chr19:10,270,913–10,271,370 | 109.4 kb | Distal (>10kb) Multiome HiCAR | 753 | |
| chr19:10,286,849–10,287,511 | 93.5 kb | Distal (>10kb) Multiome HiCAR | 621 | |
| chr19:10,288,709–10,290,833 | 91.7 kb | Distal (>10kb) Multiome HiCAR | 688 | |
| chr19:10,292,085–10,293,198 | 88.0 kb | Distal (>10kb) Multiome | 441 | |
| chr19:10,315,359–10,316,478 | 64.6 kb | Distal (>10kb) Multiome | 830 | |
| chr19:10,332,816–10,334,107 | 47.0 kb | Distal (>10kb) Multiome | 882 | |
| chr19:10,334,573–10,335,642 | 45.5 kb | Distal (>10kb) Multiome | 584 | |
| chr19:10,352,359–10,354,435 | 27.8 kb | Distal (>10kb) Multiome | 447 | |
| chr19:10,380,209–10,381,218 | 151 bp | At TSS Multiome | 874 | |
| chr19:10,388,774–10,389,141 | 8.2 kb | Proximal (<10kb) | 361 | |
| chr19:10,403,282–10,404,914 | 23.2 kb | Distal (>10kb) Multiome | 794 | |
| chr19:10,416,245–10,417,312 | 36.2 kb | Distal (>10kb) Multiome | 988 | |
| chr19:10,417,499–10,421,409 | 39.8 kb | Distal (>10kb) Multiome | 801 | |
| chr19:10,424,198–10,424,839 | 44.0 kb | Distal (>10kb) Multiome | 563 | |
| chr19:10,431,990–10,432,435 | 51.7 kb | Distal (>10kb) Multiome | 301 | |
| chr19:10,460,915–10,461,960 | 80.8 kb | Distal (>10kb) Multiome | 340 | |
| chr19:10,502,251–10,503,615 | 122.3 kb | Distal (>10kb) Multiome | 1013 | |
| chr19:10,514,009–10,514,960 | 133.9 kb | Distal (>10kb) Multiome | 172 | |
| chr19:10,517,347–10,518,104 | 137.2 kb | Distal (>10kb) Multiome | 338 | |
| chr19:10,543,499–10,544,302 | 163.3 kb | Distal (>10kb) Multiome | 617 | |
| chr19:10,565,054–10,566,439 | 185.5 kb | Distal (>10kb) Multiome | 923 | |
| chr19:10,568,225–10,569,839 | 188.5 kb | Distal (>10kb) Multiome | 871 | |
| chr19:10,602,117–10,602,945 | 221.9 kb | Distal (>10kb) Multiome | 518 | |
| chr19:10,625,339–10,625,984 | 245.0 kb | Distal (>10kb) Multiome | 451 | |
| chr19:10,653,364–10,655,129 | 273.6 kb | Distal (>10kb) Multiome | 1086 |
Genomic view of the TYK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.