This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TXN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TXN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TXN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:36,386,961–36,388,711 | 93.4 kb | Distal (>10kb) Multiome | 830 | |
| chr22:36,409,675–36,410,687 | 71.4 kb | Distal (>10kb) Multiome | 707 | |
| chr22:36,454,782–36,455,724 | 26.4 kb | Distal (>10kb) Multiome | 598 | |
| chr22:36,459,142–36,459,906 | 22.1 kb | Distal (>10kb) Multiome | 269 | |
| chr22:36,481,299–36,482,295 | 314 bp | At TSS Multiome | 842 | |
| chr22:36,506,747–36,507,706 | 25.5 kb | Distal (>10kb) Multiome | 964 | |
| chr22:36,528,683–36,529,724 | 47.7 kb | Distal (>10kb) Multiome | 1012 | |
| chr22:36,775,650–36,776,664 | 294.7 kb | Distal (>10kb) Multiome | 472 |
Genomic view of the TXN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.