TWIST2

twist family bHLH transcription factor 2 | DERMO1, Dermo-1, bHLHa39

The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found. [provided by RefSeq, Apr 2014]

Biological processes 18 terms

DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)cytoplasm (GO:0005737)cytoplasm (GO:0005737)developmental process (GO:0032502)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of osteoblast differentiation (GO:0045668)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of cell migration (GO:0030335)protein binding (GO:0005515)protein dimerization activity (GO:0046983)regulation of transcription by RNA polymerase II (GO:0006357)

Expression (TPM)