This gene encodes a membrane protein associated with the Golgi apparatus, which plays a crucial role in intracellular vesicular transport. The encoded protein is likely associated with the late (trans) Golgi compartments, which are involved in the delivery of secretory and membrane proteins to the endosome, lysosome or the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for TVP23A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TVP23A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TVP23A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:10,579,792–10,580,982 | 238.0 kb | Distal (>10kb) Multiome | 830 | |
| chr16:10,621,860–10,622,627 | 196.4 kb | Distal (>10kb) Multiome | 241 | |
| chr16:10,743,473–10,744,692 | 74.5 kb | Distal (>10kb) Multiome | 1045 | |
| chr16:10,818,333–10,818,889 | 69 bp | At TSS Multiome | 127 | |
| chr16:10,942,009–10,942,939 | 123.9 kb | Distal (>10kb) Multiome | 627 | |
| chr16:10,944,257–10,944,954 | 125.8 kb | Distal (>10kb) Multiome | 887 | |
| chr16:11,032,660–11,033,355 | 214.4 kb | Distal (>10kb) Multiome | 81 | |
| chr16:11,104,839–11,105,431 | 286.5 kb | Distal (>10kb) Multiome | 471 |
Genomic view of the TVP23A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.