This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TTYH2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTYH2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTYH2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:73,952,187–73,953,142 | 260.9 kb | Distal (>10kb) Multiome | 218 | |
| chr17:74,203,138–74,204,108 | 10.0 kb | Distal (>10kb) Multiome | 1032 | |
| chr17:74,210,321–74,210,681 | 2.9 kb | Proximal (<10kb) | 552 | |
| chr17:74,210,772–74,213,995 | 135 bp | At TSS Multiome | 756 | |
| chr17:74,245,260–74,245,769 | 32.0 kb | Distal (>10kb) Multiome | 132 | |
| chr17:74,325,836–74,326,504 | 112.6 kb | Distal (>10kb) Multiome | 237 | |
| chr17:74,351,773–74,352,296 | 138.4 kb | Distal (>10kb) Multiome | 202 | |
| chr17:74,379,476–74,379,948 | 166.1 kb | Distal (>10kb) Multiome | 522 | |
| chr17:74,431,757–74,432,660 | 218.6 kb | Distal (>10kb) Multiome | 791 | |
| chr17:74,453,513–74,454,652 | 240.6 kb | Distal (>10kb) Multiome | 751 |
Genomic view of the TTYH2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.