Predicted to enable phosphatidylinositol bisphosphate binding activity. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TTPAL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTPAL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTPAL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:44,210,101–44,211,557 | 265.0 kb | Distal (>10kb) Multiome HiCAR | 1054 | |
| chr20:44,310,737–44,311,623 | 164.6 kb | Distal (>10kb) Multiome | 908 | |
| chr20:44,475,692–44,476,318 | 1 bp | At TSS Multiome | 962 | |
| chr20:44,521,574–44,522,457 | 46.1 kb | Distal (>10kb) Multiome | 937 | |
| chr20:44,523,577–44,525,342 | 49.1 kb | Distal (>10kb) Multiome | 231 | |
| chr20:44,531,682–44,532,180 | 56.0 kb | Distal (>10kb) Multiome | 880 | |
| chr20:44,609,775–44,610,281 | 134.2 kb | Distal (>10kb) Multiome HiCAR | 727 | |
| chr20:44,642,246–44,643,140 | 166.8 kb | Distal (>10kb) Multiome | 469 | |
| chr20:44,651,099–44,652,334 | 175.9 kb | Distal (>10kb) Multiome | 641 | |
| chr20:44,745,652–44,746,316 | 270.0 kb | Distal (>10kb) Multiome | 321 |
Genomic view of the TTPAL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.