Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule bundle formation; protein polyglutamylation; and regulation of cilium beat frequency involved in ciliary motility. Predicted to act upstream of or within microtubule severing and positive regulation of cilium movement. Located in ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TTLL6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTLL6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTLL6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:48,526,970–48,527,843 | 289.7 kb | Distal (>10kb) Multiome | 167 | |
| chr17:48,543,214–48,543,984 | 273.6 kb | Distal (>10kb) Multiome | 355 | |
| chr17:48,678,104–48,678,743 | 138.5 kb | Distal (>10kb) Multiome | 453 | |
| chr17:48,719,708–48,720,337 | 97.1 kb | Distal (>10kb) Multiome | 181 | |
| chr17:48,722,219–48,723,762 | 94.1 kb | Distal (>10kb) Multiome | 220 | |
| chr17:48,728,286–48,729,570 | 88.1 kb | Distal (>10kb) Multiome | 376 | |
| chr17:48,814,522–48,814,690 | 2.4 kb | Proximal (<10kb) | 176 | |
| chr17:48,816,754–48,817,592 | 117 bp | At TSS Multiome | 589 | |
| chr17:48,830,670–48,831,519 | 14.0 kb | Distal (>10kb) Multiome | 838 | |
| chr17:48,891,910–48,893,540 | 75.5 kb | Distal (>10kb) Multiome | 1059 | |
| chr17:48,907,825–48,909,317 | 92.1 kb | Distal (>10kb) Multiome | 1011 | |
| chr17:48,944,483–48,945,203 | 127.8 kb | Distal (>10kb) Multiome | 1009 | |
| chr17:48,995,124–48,997,874 | 180.3 kb | Distal (>10kb) Multiome | 1057 | |
| chr17:49,013,253–49,014,714 | 196.7 kb | Distal (>10kb) Multiome | 480 | |
| chr17:49,022,149–49,022,993 | 205.5 kb | Distal (>10kb) Multiome | 306 | |
| chr17:49,035,641–49,036,299 | 218.9 kb | Distal (>10kb) Multiome | 338 |
Genomic view of the TTLL6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.