Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to act upstream of or within microtubule severing and protein polyglutamylation. Predicted to be located in cytosol. Predicted to be active in ciliary basal body. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for TTLL11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTLL11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTLL11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:121,550,534–121,551,203 | 542.5 kb | Distal (>10kb) Multiome HiCAR | 479 | |
| chr9:122,092,682–122,093,762 | 62 bp | At TSS Multiome | 771 | |
| chr9:122,099,169–122,100,386 | 5.9 kb | Proximal (<10kb) | 262 | |
| chr9:122,159,157–122,160,157 | 66.5 kb | Distal (>10kb) Multiome | 592 | |
| chr9:122,213,553–122,214,655 | 120.8 kb | Distal (>10kb) Multiome | 629 | |
| chr9:122,219,092–122,220,535 | 126.2 kb | Distal (>10kb) Multiome | 158 | |
| chr9:122,228,256–122,229,326 | 135.5 kb | Distal (>10kb) Multiome | 307 | |
| chr9:122,264,447–122,265,544 | 171.5 kb | Distal (>10kb) Multiome | 1042 | |
| chr9:122,827,785–122,828,901 | 735.2 kb | Distal (>10kb) Multiome HiCAR | 765 |
Genomic view of the TTLL11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.