This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1. The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance. [provided by RefSeq, May 2013]
Transcription factors with Perturb-seq knockdown data for TTI2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTI2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTI2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:33,223,201–33,224,129 | 289.5 kb | Distal (>10kb) Multiome | 103 | |
| chr8:33,471,825–33,473,740 | 39.9 kb | Distal (>10kb) Multiome | 999 | |
| chr8:33,484,346–33,485,645 | 28.1 kb | Distal (>10kb) Multiome | 940 | |
| chr8:33,512,345–33,515,139 | 1.6 kb | Proximal (<10kb) Multiome | 1310 | |
| chr8:33,516,059–33,516,260 | 3.0 kb | Proximal (<10kb) | 122 | |
| chr8:33,543,087–33,543,854 | 30.3 kb | Distal (>10kb) Multiome | 102 | |
| chr8:33,566,077–33,567,716 | 54.0 kb | Distal (>10kb) Multiome | 711 | |
| chr8:33,626,086–33,627,037 | 113.3 kb | Distal (>10kb) Multiome | 118 |
Genomic view of the TTI2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.