Transcription factors with Perturb-seq knockdown data for TTC6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTC6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTC6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:37,587,658–37,588,927 | 6.7 kb | Proximal (<10kb) | 732 | |
| chr14:37,591,282–37,593,025 | 3.9 kb | Proximal (<10kb) Multiome | 515 | |
| chr14:37,594,092–37,596,733 | 353 bp | At TSS Multiome | 1108 | |
| chr14:37,596,873–37,597,337 | 1.2 kb | Proximal (<10kb) | 62 | |
| chr14:37,597,595–37,599,188 | 2.0 kb | Proximal (<10kb) | 235 | |
| chr14:37,599,318–37,600,383 | 3.7 kb | Proximal (<10kb) | 262 | |
| chr14:37,622,164–37,623,020 | 26.9 kb | Distal (>10kb) Multiome | 215 |
Genomic view of the TTC6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.