Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TTC38. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTC38 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTC38, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:45,978,612–45,979,356 | 289.0 kb | Distal (>10kb) Multiome | 567 | |
| chr22:46,013,459–46,014,306 | 254.2 kb | Distal (>10kb) Multiome | 814 | |
| chr22:46,035,443–46,036,717 | 232.1 kb | Distal (>10kb) Multiome | 735 | |
| chr22:46,061,373–46,062,193 | 206.3 kb | Distal (>10kb) Multiome | 257 | |
| chr22:46,070,177–46,072,638 | 197.0 kb | Distal (>10kb) Multiome | 557 | |
| chr22:46,116,470–46,116,929 | 151.4 kb | Distal (>10kb) Multiome | 471 | |
| chr22:46,149,521–46,151,433 | 117.7 kb | Distal (>10kb) Multiome HiCAR | 562 | |
| chr22:46,201,176–46,201,774 | 66.5 kb | Distal (>10kb) Multiome | 124 | |
| chr22:46,249,918–46,250,866 | 17.7 kb | Distal (>10kb) Multiome | 831 | |
| chr22:46,262,531–46,263,383 | 5.1 kb | Proximal (<10kb) Multiome | 169 | |
| chr22:46,267,542–46,268,277 | 112 bp | At TSS Multiome | 725 | |
| chr22:46,296,072–46,297,498 | 28.7 kb | Distal (>10kb) Multiome | 810 | |
| chr22:46,335,274–46,336,005 | 67.6 kb | Distal (>10kb) Multiome | 911 | |
| chr22:46,536,494–46,538,050 | 269.6 kb | Distal (>10kb) Multiome | 337 | |
| chr22:46,563,410–46,564,218 | 295.7 kb | Distal (>10kb) Multiome | 541 |
Genomic view of the TTC38 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.