Enables RNA binding activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TSR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:2,041,423–2,042,366 | 294.5 kb | Distal (>10kb) Multiome | 834 | |
| chr17:2,048,764–2,051,218 | 287.4 kb | Distal (>10kb) Multiome | 658 | |
| chr17:2,053,643–2,054,179 | 282.7 kb | Distal (>10kb) Multiome | 473 | |
| chr17:2,054,616–2,055,766 | 281.4 kb | Distal (>10kb) Multiome | 544 | |
| chr17:2,058,401–2,059,503 | 277.6 kb | Distal (>10kb) Multiome | 366 | |
| chr17:2,302,778–2,304,288 | 32.8 kb | Distal (>10kb) Multiome | 770 | |
| chr17:2,336,166–2,337,712 | 18 bp | At TSS Multiome | 896 | |
| chr17:2,337,831–2,338,296 | 1.4 kb | Proximal (<10kb) | 392 | |
| chr17:2,392,290–2,394,855 | 56.4 kb | Distal (>10kb) Multiome | 788 | |
| chr17:2,396,361–2,397,494 | 60.5 kb | Distal (>10kb) Multiome | 546 | |
| chr17:2,398,260–2,402,837 | 63.2 kb | Distal (>10kb) Multiome | 1128 | |
| chr17:2,511,517–2,512,317 | 175.5 kb | Distal (>10kb) Multiome | 698 | |
| chr17:2,592,971–2,594,792 | 257.2 kb | Distal (>10kb) Multiome | 853 |
Genomic view of the TSR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.