Enables enzyme binding activity. Involved in pore complex assembly; protein localization to plasma membrane; and protein maturation. Located in plasma membrane. Part of pore complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TSPAN33. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSPAN33 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSPAN33, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:128,862,244–128,863,913 | 281.9 kb | Distal (>10kb) Multiome | 736 | |
| chr7:128,868,986–128,870,326 | 275.1 kb | Distal (>10kb) Multiome | 557 | |
| chr7:128,879,898–128,880,508 | 264.5 kb | Distal (>10kb) Multiome | 323 | |
| chr7:128,890,731–128,891,934 | 253.3 kb | Distal (>10kb) Multiome | 231 | |
| chr7:128,911,320–128,912,136 | 233.0 kb | Distal (>10kb) Multiome | 216 | |
| chr7:128,937,568–128,938,346 | 206.7 kb | Distal (>10kb) Multiome | 392 | |
| chr7:129,054,212–129,055,537 | 89.7 kb | Distal (>10kb) Multiome | 1049 | |
| chr7:129,144,393–129,145,068 | 1 bp | At TSS Multiome | 477 | |
| chr7:129,168,405–129,170,130 | 24.6 kb | Distal (>10kb) Multiome | 302 | |
| chr7:129,188,088–129,189,694 | 43.9 kb | Distal (>10kb) Multiome | 603 | |
| chr7:129,224,228–129,225,767 | 80.2 kb | Distal (>10kb) Multiome | 899 | |
| chr7:129,433,659–129,435,261 | 289.7 kb | Distal (>10kb) Multiome | 770 |
Genomic view of the TSPAN33 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.