The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TSPAN15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSPAN15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSPAN15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:69,179,817–69,180,725 | 271.3 kb | Distal (>10kb) Multiome | 900 | |
| chr10:69,317,873–69,319,610 | 132.8 kb | Distal (>10kb) Multiome | 675 | |
| chr10:69,392,338–69,392,832 | 58.8 kb | Distal (>10kb) Multiome | 454 | |
| chr10:69,408,469–69,409,338 | 42.6 kb | Distal (>10kb) Multiome | 705 | |
| chr10:69,449,843–69,450,266 | 1.5 kb | Proximal (<10kb) Multiome | 301 | |
| chr10:69,450,797–69,452,284 | 41 bp | At TSS Multiome | 508 | |
| chr10:69,629,756–69,630,921 | 178.8 kb | Distal (>10kb) Multiome | 567 |
Genomic view of the TSPAN15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.