Enables mRNA (adenine-N1-)-methyltransferase activity. Involved in mRNA processing. Part of tRNA (m1A) methyltransferase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TRMT61A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRMT61A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRMT61A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:103,333,053–103,335,386 | 195.1 kb | Distal (>10kb) Multiome | 1004 | |
| chr14:103,384,755–103,386,021 | 143.9 kb | Distal (>10kb) Multiome | 863 | |
| chr14:103,518,427–103,519,043 | 10.4 kb | Distal (>10kb) Multiome | 404 | |
| chr14:103,520,443–103,523,552 | 6.2 kb | Proximal (<10kb) Multiome | 756 | |
| chr14:103,528,671–103,529,619 | 57 bp | At TSS Multiome | 726 | |
| chr14:103,561,982–103,563,356 | 33.6 kb | Distal (>10kb) Multiome | 781 | |
| chr14:103,628,110–103,630,126 | 99.9 kb | Distal (>10kb) Multiome | 909 | |
| chr14:103,715,029–103,716,504 | 186.4 kb | Distal (>10kb) Multiome | 709 |
Genomic view of the TRMT61A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.