The protein encoded by this gene is of unknown function. However, it is orthologous to the mouse Trmt2a gene and contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant expression being a possible biomarker in certain breast cancers. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Transcription factors with Perturb-seq knockdown data for TRMT2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRMT2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRMT2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:19,854,381–19,855,705 | 262.3 kb | Distal (>10kb) Multiome | 1014 | |
| chr22:19,891,576–19,892,031 | 225.5 kb | Distal (>10kb) Multiome | 631 | |
| chr22:19,959,058–19,959,828 | 157.8 kb | Distal (>10kb) Multiome | 576 | |
| chr22:19,962,339–19,962,798 | 154.7 kb | Distal (>10kb) Multiome | 442 | |
| chr22:19,986,350–19,987,426 | 130.1 kb | Distal (>10kb) Multiome | 539 | |
| chr22:20,016,068–20,017,437 | 100.4 kb | Distal (>10kb) Multiome | 640 | |
| chr22:20,020,662–20,021,745 | 96.2 kb | Distal (>10kb) Multiome | 718 | |
| chr22:20,079,663–20,080,743 | 37.1 kb | Distal (>10kb) Multiome | 994 | |
| chr22:20,116,628–20,118,048 | 97 bp | At TSS Multiome | 999 | |
| chr22:20,130,806–20,131,896 | 14.0 kb | Distal (>10kb) Multiome | 525 | |
| chr22:20,203,393–20,204,086 | 86.6 kb | Distal (>10kb) Multiome | 292 | |
| chr22:20,243,636–20,244,300 | 126.8 kb | Distal (>10kb) Multiome | 251 | |
| chr22:20,267,373–20,268,700 | 151.2 kb | Distal (>10kb) Multiome | 449 | |
| chr22:20,298,366–20,300,076 | 181.9 kb | Distal (>10kb) Multiome | 538 | |
| chr22:20,319,527–20,320,815 | 202.9 kb | Distal (>10kb) Multiome | 805 | |
| chr22:20,393,744–20,394,682 | 276.9 kb | Distal (>10kb) Multiome | 854 |
Genomic view of the TRMT2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.