Enables protein heterodimerization activity; protein methyltransferase activity; and tRNA methyltransferase activator activity. Involved in macromolecule methylation and positive regulation of macromolecule metabolic process. Located in nucleoplasm and perinuclear region of cytoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TRMT112. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRMT112 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRMT112, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:64,028,126–64,028,898 | 288.9 kb | Distal (>10kb) Multiome | 168 | |
| chr11:64,165,638–64,166,698 | 151.3 kb | Distal (>10kb) Multiome | 811 | |
| chr11:64,184,927–64,186,817 | 131.6 kb | Distal (>10kb) Multiome | 1091 | |
| chr11:64,225,548–64,226,862 | 91.4 kb | Distal (>10kb) Multiome | 776 | |
| chr11:64,230,074–64,231,130 | 87.1 kb | Distal (>10kb) Multiome | 715 | |
| chr11:64,233,950–64,235,296 | 83.1 kb | Distal (>10kb) Multiome | 590 | |
| chr11:64,240,398–64,242,687 | 76.3 kb | Distal (>10kb) Multiome | 982 | |
| chr11:64,246,274–64,248,065 | 70.4 kb | Distal (>10kb) Multiome | 802 | |
| chr11:64,250,699–64,251,842 | 66.1 kb | Distal (>10kb) Multiome | 498 | |
| chr11:64,268,509–64,270,920 | 47.5 kb | Distal (>10kb) Multiome | 1093 | |
| chr11:64,271,352–64,271,994 | 46.0 kb | Distal (>10kb) Multiome | 595 | |
| chr11:64,284,095–64,286,666 | 31.8 kb | Distal (>10kb) Multiome | 807 | |
| chr11:64,300,129–64,301,268 | 16.5 kb | Distal (>10kb) Multiome | 591 | |
| chr11:64,304,032–64,307,072 | 11.2 kb | Distal (>10kb) Multiome | 994 | |
| chr11:64,316,954–64,319,418 | 1.5 kb | Proximal (<10kb) Multiome | 1039 | |
| chr11:64,340,711–64,341,211 | 23.4 kb | Distal (>10kb) Multiome | 212 | |
| chr11:64,342,083–64,343,227 | 25.1 kb | Distal (>10kb) Multiome | 543 | |
| chr11:64,358,792–64,359,751 | 41.6 kb | Distal (>10kb) Multiome | 577 | |
| chr11:64,448,870–64,449,995 | 131.4 kb | Distal (>10kb) Multiome | 490 |
Genomic view of the TRMT112 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.