Enables tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity. Involved in tRNA methylation. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TRMO. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRMO upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRMO, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:97,632,371–97,634,267 | 289.0 kb | Distal (>10kb) Multiome | 1027 | |
| chr9:97,696,750–97,697,733 | 225.2 kb | Distal (>10kb) Multiome | 836 | |
| chr9:97,710,703–97,711,693 | 211.3 kb | Distal (>10kb) Multiome | 257 | |
| chr9:97,741,053–97,741,796 | 181.1 kb | Distal (>10kb) Multiome | 305 | |
| chr9:97,803,235–97,804,055 | 118.9 kb | Distal (>10kb) Multiome | 679 | |
| chr9:97,853,103–97,855,002 | 68.5 kb | Distal (>10kb) Multiome | 323 | |
| chr9:97,922,022–97,923,085 | 83 bp | At TSS Multiome | 1110 | |
| chr9:97,923,790–97,923,994 | 1.3 kb | Proximal (<10kb) | 330 | |
| chr9:97,982,380–97,985,451 | 62.2 kb | Distal (>10kb) Multiome | 994 | |
| chr9:98,056,283–98,057,271 | 134.2 kb | Distal (>10kb) Multiome | 868 | |
| chr9:98,087,291–98,088,183 | 165.3 kb | Distal (>10kb) Multiome | 281 | |
| chr9:98,118,693–98,119,508 | 196.7 kb | Distal (>10kb) Multiome | 752 | |
| chr9:98,191,695–98,193,531 | 270.5 kb | Distal (>10kb) Multiome | 795 | |
| chr9:98,218,786–98,219,246 | 296.5 kb | Distal (>10kb) Multiome | 178 |
Genomic view of the TRMO locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.