Predicted to enable chromatin binding activity; identical protein binding activity; and zinc ion binding activity. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TRIM66. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM66 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM66, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:8,593,749–8,594,754 | 77.7 kb | Distal (>10kb) Multiome | 587 | |
| chr11:8,671,011–8,671,925 | 473 bp | At TSS Multiome | 223 | |
| chr11:8,682,170–8,683,291 | 10.8 kb | Distal (>10kb) Multiome | 956 | |
| chr11:8,687,635–8,689,327 | 17.2 kb | Distal (>10kb) Multiome | 1023 | |
| chr11:8,700,857–8,701,532 | 29.4 kb | Distal (>10kb) Multiome | 216 | |
| chr11:8,713,673–8,714,258 | 42.0 kb | Distal (>10kb) Multiome | 102 | |
| chr11:8,800,375–8,801,511 | 129.2 kb | Distal (>10kb) Multiome | 167 | |
| chr11:8,810,380–8,811,275 | 138.9 kb | Distal (>10kb) Multiome HiCAR | 360 | |
| chr11:8,813,629–8,814,688 | 142.0 kb | Distal (>10kb) Multiome HiCAR | 380 | |
| chr11:8,870,357–8,871,640 | 199.1 kb | Distal (>10kb) Multiome | 506 | |
| chr11:8,910,714–8,911,839 | 239.4 kb | Distal (>10kb) Multiome | 722 | |
| chr11:8,963,907–8,965,344 | 292.5 kb | Distal (>10kb) Multiome | 912 |
Genomic view of the TRIM66 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.