TRIM62
tripartite motif containing 62 | DEAR1, FLJ10759

Enables identical protein binding activity; transcription coactivator activity; and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of viral transcription; positive regulation of NF-kappaB transcription factor activity; and positive regulation of antifungal innate immune response. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 25 terms
cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)identical protein binding (GO:0042802)innate immune response (GO:0045087)innate immune response (GO:0045087)negative regulation of viral transcription (GO:0032897)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of antifungal innate immune response (GO:1905036)positive regulation of antifungal innate immune response (GO:1905036)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)protein K27-linked ubiquitination (GO:0044314)protein binding (GO:0005515)protein ubiquitination (GO:0016567)regulation of viral entry into host cell (GO:0046596)transcription coactivator activity (GO:0003713)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin-protein transferase activity (GO:0004842)viral release from host cell (GO:0019076)zinc ion binding (GO:0008270)
Expression (TPM)
TRIM62 — as a Regulated Gene

TFs regulating TRIM62 0 TFs

Transcription factors with Perturb-seq knockdown data for TRIM62. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM62 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to TRIM62

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM62, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:32,886,388–32,887,030 295.3 kb Distal (>10kb) Multiome 917
chr1:32,892,705–32,893,946 289.0 kb Distal (>10kb) Multiome 444
chr1:32,901,143–32,901,775 280.6 kb Distal (>10kb) Multiome 393
chr1:32,963,782–32,965,243 217.1 kb Distal (>10kb) Multiome 882
chr1:32,972,824–32,973,439 208.9 kb Distal (>10kb) Multiome 489
chr1:33,036,391–33,037,199 145.1 kb Distal (>10kb) Multiome 948
chr1:33,080,764–33,081,783 100.9 kb Distal (>10kb) Multiome 556
chr1:33,127,180–33,127,648 54.6 kb Distal (>10kb) Multiome 877
chr1:33,152,752–33,153,392 28.9 kb Distal (>10kb) Multiome 151
chr1:33,180,551–33,182,306 1.1 kb Proximal (<10kb) Multiome 692
chr1:33,255,428–33,256,795 73.7 kb Distal (>10kb) Multiome 509
chr1:33,349,195–33,350,690 167.9 kb Distal (>10kb) Multiome 874
chr1:33,363,845–33,364,278 182.0 kb Distal (>10kb) Multiome 214
chr1:33,430,392–33,431,511 249.0 kb Distal (>10kb) Multiome 555
chr1:33,472,141–33,472,925 290.5 kb Distal (>10kb) Multiome 656

Genome Browser

Genomic view of the TRIM62 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:32,876,388 – 33,482,925
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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