Enables ubiquitin protein ligase activity. Involved in negative regulation of inflammatory response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K48-linked ubiquitination. Located in cytosol; intercellular bridge; and nucleoplasm. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TRIM45. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM45 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM45, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:116,909,571–116,911,117 | 211.7 kb | Distal (>10kb) Multiome | 645 | |
| chr1:117,059,404–117,060,970 | 61.6 kb | Distal (>10kb) Multiome | 909 | |
| chr1:117,120,593–117,121,160 | 588 bp | At TSS | 73 | |
| chr1:117,121,317–117,122,916 | 170 bp | At TSS Multiome | 747 | |
| chr1:117,268,677–117,269,503 | 147.5 kb | Distal (>10kb) Multiome HiCAR | 284 | |
| chr1:117,366,239–117,368,025 | 245.4 kb | Distal (>10kb) Multiome | 887 |
Genomic view of the TRIM45 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.