This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for TRIM38. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM38 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM38, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:25,963,471–25,963,874 | 670 bp | At TSS | 193 | |
| chr6:25,992,391–25,993,479 | 29.9 kb | Distal (>10kb) Multiome | 1012 | |
| chr6:26,020,104–26,022,401 | 57.6 kb | Distal (>10kb) Multiome | 920 | |
| chr6:26,025,866–26,027,859 | 63.5 kb | Distal (>10kb) Multiome | 1194 | |
| chr6:26,031,341–26,032,990 | 69.4 kb | Distal (>10kb) Multiome | 1083 | |
| chr6:26,033,113–26,034,309 | 70.9 kb | Distal (>10kb) Multiome | 800 | |
| chr6:26,054,926–26,057,287 | 92.5 kb | Distal (>10kb) Multiome | 1174 | |
| chr6:26,103,452–26,105,109 | 141.1 kb | Distal (>10kb) Multiome | 1169 | |
| chr6:26,122,481–26,124,909 | 160.2 kb | Distal (>10kb) Multiome | 1216 | |
| chr6:26,125,788–26,126,592 | 163.4 kb | Distal (>10kb) Multiome | 670 | |
| chr6:26,156,184–26,158,744 | 195.3 kb | Distal (>10kb) Multiome | 1310 | |
| chr6:26,171,798–26,172,499 | 209.2 kb | Distal (>10kb) Multiome | 580 | |
| chr6:26,183,128–26,184,377 | 220.9 kb | Distal (>10kb) Multiome | 311 | |
| chr6:26,187,874–26,189,538 | 226.3 kb | Distal (>10kb) Multiome | 1053 | |
| chr6:26,196,695–26,197,676 | 234.5 kb | Distal (>10kb) Multiome | 842 | |
| chr6:26,198,203–26,200,197 | 236.6 kb | Distal (>10kb) Multiome | 939 | |
| chr6:26,203,791–26,205,119 | 241.7 kb | Distal (>10kb) Multiome | 1071 | |
| chr6:26,214,872–26,218,468 | 254.1 kb | Distal (>10kb) Multiome | 1096 | |
| chr6:26,223,716–26,224,480 | 261.2 kb | Distal (>10kb) Multiome | 507 | |
| chr6:26,224,856–26,226,566 | 262.4 kb | Distal (>10kb) Multiome | 451 | |
| chr6:26,239,944–26,240,920 | 277.6 kb | Distal (>10kb) Multiome | 375 | |
| chr6:26,249,682–26,251,138 | 287.5 kb | Distal (>10kb) Multiome | 731 | |
| chr6:26,251,339–26,252,079 | 288.9 kb | Distal (>10kb) Multiome | 445 |
Genomic view of the TRIM38 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.