The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TRIM35. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM35 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM35, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:27,147,013–27,147,707 | 163.8 kb | Distal (>10kb) Multiome | 88 | |
| chr8:27,274,263–27,275,075 | 36.7 kb | Distal (>10kb) Multiome | 573 | |
| chr8:27,310,458–27,311,925 | 159 bp | At TSS Multiome | 871 | |
| chr8:27,315,336–27,315,612 | 4.1 kb | Proximal (<10kb) | 404 | |
| chr8:27,490,586–27,491,648 | 179.8 kb | Distal (>10kb) Multiome | 837 | |
| chr8:27,592,228–27,592,758 | 281.2 kb | Distal (>10kb) Multiome | 524 | |
| chr8:27,608,493–27,608,956 | 297.5 kb | Distal (>10kb) Multiome | 168 |
Genomic view of the TRIM35 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.