Transcription factors with Perturb-seq knockdown data for TRGV7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRGV7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRGV7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:38,329,010–38,330,278 | 5.2 kb | Proximal (<10kb) | 103 | |
| chr7:38,330,757–38,331,521 | 4.0 kb | Proximal (<10kb) | 166 | |
| chr7:38,331,896–38,332,124 | 3.4 kb | Proximal (<10kb) | 106 | |
| chr7:38,332,228–38,332,845 | 2.7 kb | Proximal (<10kb) | 201 | |
| chr7:38,335,451–38,336,337 | at TSS | At TSS | 492 | |
| chr7:38,341,206–38,341,751 | 5.7 kb | Proximal (<10kb) | 243 | |
| chr7:38,345,442–38,345,962 | 9.9 kb | Proximal (<10kb) | 80 |
Genomic view of the TRGV7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.